Every living cell conatins a complete copy of the genetic material that is required for all its activities. In the case of the human genome the approximately 3 billion base pairs in such a copy correspond to a DNA molecule with a length of several meters. Nonetheless, this DNA is packed into a cell with a diameter of about 5 micrometers, which means that is must be highly compacted. This organisation is partly achieved by the formation of nucleosomes, as show in this structural model.
We can see how the DNA is wound around a core of proteins in two big loops.
By coloring the negatively charged (acidic) residues red and the positively charged (basc) residues blue, we can see a charge distribution. The "sides" of the nucleosome particle, which interact with the predominantly negatively charged phosphate backbone of the DNA, are positively charged. The top and bottom regions of the nucleosome are not so uniformly charged.